139023-58-8
Chemical Structure
Manumycin B
- CAS No.: 139023-58-8
- Formula:C28H34N2O7
- Molecular Weight:510.58
IUPAC Name: (R,E)-N-((1S,5S,6R)-5-hydroxy-5-((1E,3E,5E)-7-((2-hydroxy-5-oxocyclopent-1-en-1-yl)amino)-7-oxohepta-1,3,5-trien-1-yl)-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)-2,4-dimethyloct-2-enamide
InChIKey: ZGICGDCGECBVTD-LOWJZYKPSA-N
SMILES: CCCC[C@@H](C)/C=C(C)/C(NC1=C[C@](/C=C/C=C/C=C/C(NC2=C(O)CCC2=O)=O)(O)[C@]3([H])O[C@]3([H])C1=O)=O
Biological Activity: Manumycin B is an antibiobic, and exhibits antitumor activity. Manumycin B is an inhibitor for acetylcholinesterase (AChE) with an IC50 of 15 mM[1][2].
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Manumycin B | Manumycin B is an antibiobic, and exhibits antitumor activity. Manumycin B is an inhibitor for acetylcholinesterase (AChE) with an IC50 of 15 mM. | |||||||||||||||||||||
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- [1]. Zheng ZH, et al., Isolation and characterization of N98-1272 A, B and C, selective acetylcholinesterase inhibitors from metabolites of an actinomycete strain. J Enzyme Inhib Med Chem. 2007 Feb;22(1):43-9. [Content Brief]
- [2]. Grové J J C, et al., The first total synthesis of a type II manumycin antibiotic,(+)-TMC-1 A: the total syntheses of (–)-LL-C10037β and (+)-manumycin B[J]. Chemical Communications, 1999 (5): 421-422.
Keywords
