139585-03-8
139585-03-8
Chemical Structure
ARP
Synonym(s): Aldehyde reactive probe
- CAS No.: 139585-03-8
- Formula:C12H21N5O4S
- Molecular Weight:331.39
InChIKey: KYHUBFIOWQTECH-LAEOZQHASA-N
SMILES: NOCC(NNC(CCCC[C@H]1[C@]2([H])[C@](NC(N2)=O)([H])CS1)=O)=O
Biological Activity: ARP (Aldehyde reactive probe) is an aldehyde-reactive probe. ARP specifically labels AP sites in DNA with biotin residues. ARP detects abasic sites induced by RNA oxidation. ARP is suitable for studies involving the quantification of AP sites, or the detection of other aldehyde-containing DNA damages and abasic sites induced by RNA oxidation[1][2].
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ARP | 95.24% | ARP (Aldehyde reactive probe) is an aldehyde-reactive probe. ARP specifically labels AP sites in DNA with biotin residues. ARP detects abasic sites induced by RNA oxidation. ARP is suitable for studies involving the quantification of AP sites, or the detection of other aldehyde-containing DNA damages and abasic sites induced by RNA oxidation. | ||||||||||||||||||||
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References
- [1]. Kubo K, et al. A novel, sensitive, and specific assay for abasic sites, the most commonly produced DNA lesion. Biochemistry. 1992;31(14):3703-3708. [Content Brief]
- [2]. Tanaka M, et al. An assay for RNA oxidation induced abasic sites using the Aldehyde Reactive Probe. Free Radic Res. 2011;45(2):237-247. [Content Brief]
Keywords
