1398065-88-7
1398065-88-7
Chemical Structure
Guanfacine-d2 hydrochloride
- CAS No.: 1398065-88-7
- Formula:C9H8D2Cl3N3O
- Molecular Weight:284.57
IUPAC Name: N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide-2,2-d2 hydrochloride
InChIKey: DGFYECXYGUIODH-YLENYTFQSA-N
SMILES: N=C(N)NC(C([2H])([2H])C1=C(C=CC=C1Cl)Cl)=O.Cl
Biological Activity: Guanfacine-d2 (hydrochloride) is the deuterium labeled Guanfacine hydrochloride. Guanfacine hydrochloride, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors[1][2].
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Guanfacine-d2 hydrochloride | Guanfacine-d2 (hydrochloride) is the deuterium labeled Guanfacine hydrochloride. Guanfacine hydrochloride, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors. | |||||||||||||||||||||
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Guanfacine hydrochloride (Standard) | 99.95% | Guanfacine (hydrochloride) (Standard) is the analytical standard of Guanfacine (hydrochloride). This product is intended for research and analytical applications. Guanfacine hydrochloride is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD). | ||||||||||||||||||||
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Guanfacine-13C,d5 hydrochloride | Guanfacine-13C,d5 hydrochloride is the deuterium and 13C labeled Guanfacine hydrochloride (HY-17416). Guanfacine hydrochloride is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD). | |||||||||||||||||||||
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Guanfacine hydrochloride | 99.98% | Guanfacine hydrochloride is an orally active and blood-brain barrier permeability noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD). | ||||||||||||||||||||
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References
- [1]. Wang J, et al. Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion. J Neurosci Res. 2010 Mar;88(4):807-15. [Content Brief]
- [2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
