1402055-25-7
Chemical Structure
Cdc7-IN-1
- CAS No.: 1402055-25-7
- Formula:C21H16ClN3O4
- Molecular Weight:409.82
IUPAC Name: ethyl (Z)-5-((1H-pyrrolo[2,3-b]pyridin-3-yl)methylene)-2-((2-chlorophenyl)amino)-4-oxo-4,5-dihydrofuran-3-carboxylate
InChIKey: UBRRAOXFTDKJKM-YBEGLDIGSA-N
SMILES: O=C1C(C(OCC)=O)=C(NC2=C(Cl)C=CC=C2)O/C1=C\C3=CNC4=C3C=CC=N4
Biological Activity: Cdc7-IN-1 (Compound 13) is a highly potent, selective and ATP competitive inhibitor of Cdc7 kinase, with an IC50 value of 0.6 nM at 1 mM ATP and with slow off-rate characteristics. Cdc7-IN-1 potently inhibits Cdc7 activity in cancer cells, and effectively induces cell death[1].
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Cdc7-IN-1 | 99.32% | Cdc7-IN-1 (Compound 13) is a highly potent, selective and ATP competitive inhibitor of Cdc7 kinase, with an IC50 value of 0.6 nM at 1 mM ATP and with slow off-rate characteristics. Cdc7-IN-1 potently inhibits Cdc7 activity in cancer cells, and effectively induces cell death. | ||||||||||||||||||||
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Cdc7-IN-1 (Standard) | ≥98% | Cdc7-IN-1 (Standard) is the analytical standard of Cdc7-IN-1 (HY-101523). This product is intended for research and analytical applications. Cdc7-IN-1 (Compound 13) is a highly potent, selective and ATP competitive inhibitor of Cdc7 kinase, with an IC50 value of 0.6 nM at 1 mM ATP and with slow off-rate characteristics. Cdc7-IN-1 potently inhibits Cdc7 activity in cancer cells, and effectively induces cell death. | ||||||||||||||||||||
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Keywords
