1402086-20-7
1402086-20-7
Chemical Structure
Afatinib impurity 11
- CAS No.: 1402086-20-7
- Formula:C21H18ClFN4O3
- Molecular Weight:428.84
IUPAC Name: (S)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)acrylamide
InChIKey: MLHDLQIHGCIPJQ-ZDUSSCGKSA-N
SMILES: O=C(NC1=C(C=C2C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)=C1)O[C@H]4CCOC4)C=C
Biological Activity: Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Afatinib impurity 11 | 99.10% | Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. | ||||||||||||||||||||
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References
Keywords
