1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
    Autophagy
  2. EGFR
    Autophagy
  3. Afatinib impurity 11

Afatinib impurity 11 

Cat. No.: HY-133780
Handling Instructions

Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively.

For research use only. We do not sell to patients.

Afatinib impurity 11 Chemical Structure

Afatinib impurity 11 Chemical Structure

CAS No. : 1402086-20-7

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Description

Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively[1].

Molecular Weight

428.84

Formula

C₂₁H₁₈ClFN₄O₃

CAS No.

1402086-20-7

SMILES

O=C(NC1=C(C=C2C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)=C1)O[[email protected]]4CCOC4)C=C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Afatinib impurity 11Afatinib impurity11Afatinib impurity-11EGFRAutophagyEpidermal growth factor receptorErbB-1HER1AfatinibimpurityEGFRwtEGFRL858REGFRL858R/T790MHER2Inhibitorinhibitorinhibit

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Afatinib impurity 11
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