2. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
    Autophagy
  3. EGFR
    Autophagy
  4. Afatinib impurity 11

Afatinib impurity 11 

Cat. No.: HY-133780 Purity: 99.10% ee.: 99.28%
COA Handling Instructions

Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively.

For research use only. We do not sell to patients.

Afatinib impurity 11 Chemical Structure

Afatinib impurity 11 Chemical Structure

CAS No. : 1402086-20-7

Size Price Stock Quantity
1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively[1].

Molecular Weight

428.84

Appearance

Solid

Formula

C21H18ClFN4O3
CAS No.
SMILES

O=C(NC1=C(C=C2C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)=C1)O[[email protected]]4CCOC4)C=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (29.15 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3319 mL 11.6594 mL 23.3187 mL
5 mM 0.4664 mL 2.3319 mL 4.6637 mL
10 mM 0.2332 mL 1.1659 mL 2.3319 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 4.25 mg/mL (9.91 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2 mg/mL (4.66 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.10% ee.: 99.28%

COA (252 KB) HNMR (433 KB) NP-HPLC (272 KB) LCMS (110 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Afatinib impurity 111402086-20-7Afatinib impurity11Afatinib impurity-11EGFRAutophagyEpidermal growth factor receptorErbB-1HER1AfatinibimpurityEGFRwtEGFRL858REGFRL858R/T790MHER2Inhibitorinhibitorinhibit

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