1403894-72-3
1403894-72-3
Chemical Structure
Mesdopetam
Synonym(s): IRL790
- CAS No.: 1403894-72-3
- Formula:C12H18FNO3S
- Molecular Weight:275.34
IUPAC Name: N-(2-(3-fluoro-5-(methylsulfonyl)phenoxy)ethyl)propan-1-amine
InChIKey: OSBPYFBXSLJHCR-UHFFFAOYSA-N
SMILES: CCCNCCOC1=CC(S(=O)(C)=O)=CC(F)=C1
Biological Activity: Mesdopetam (IRL790) is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam is used for the research of motor and psychiatric complications in Parkinson disease[1][2].
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Mesdopetam | Mesdopetam (IRL790) is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam is used for the research of motor and psychiatric complications in Parkinson disease. | |||||||||||||||||||||
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References
- [1]. Waters S, et al. Preclinical Pharmacology of [2-(3-Fluoro-5-Methanesulfonyl-phenoxy)Ethyl](Propyl)amine (IRL790), a Novel Dopamine Transmission Modulator for the Treatment of Motor and Psychiatric Complications in Parkinson Disease. J Pharmacol Exp Ther. [Content Brief]
- [2]. Becanovic K, et al. Effects of a Novel Psychomotor Stabilizer, IRL790, on Biochemical Measures of Synaptic Markers and Neurotransmission. J Pharmacol Exp Ther. 2020;374(1):126-133. [Content Brief]
Keywords
