1. GPCR/G Protein Neuronal Signaling
  2. Dopamine Receptor
  3. Mesdopetam

Mesdopetam (IRL790) is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam is used for the research of motor and psychiatric complications in Parkinson disease.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Mesdopetam hemitartrate) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Mesdopetam Chemical Structure

Mesdopetam Chemical Structure

CAS No. : 1403894-72-3

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Description

Mesdopetam (IRL790) is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam is used for the research of motor and psychiatric complications in Parkinson disease[1][2].

IC50 & Target[1]

D3 Receptor

 

In Vivo

Mesdopetam (IRL790) (3.7, 11, 33, or 100 µmol/kg) dose-dependently inhibits the behavioral activation following pretreatment with D-amphetamine or MK-80[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 3.7, 11, 33, or 100 µmol/kg (synthesized in-house as HCl salt, was dissolved in physiologic saline (0.9% w/v NaCl)
Administration: s.c. was administered subcutaneously 4 min before the start of recording
Result: Dose-dependently inhibited the behavioral activation following pretreatment with D-amphetamine or MK-801.
Clinical Trial
Molecular Weight

275.34

Formula

C12H18FNO3S

CAS No.
SMILES

CCCNCCOC1=CC(S(=O)(C)=O)=CC(F)=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Mesdopetam Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Mesdopetam
Cat. No.:
HY-109150
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