1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Mesdopetam hemitartrate

Mesdopetam hemitartrate (Synonyms: IRL790 hemitartrate)

Cat. No.: HY-109150A Purity: 99.90%
Handling Instructions

Mesdopetam (IRL790) hemitartrate is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam hemitartrate is used for the research of motor and psychiatric complications in Parkinson disease.

For research use only. We do not sell to patients.

Mesdopetam hemitartrate Chemical Structure

Mesdopetam hemitartrate Chemical Structure

CAS No. : 2562346-14-7

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10 mg USD 170 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Mesdopetam (IRL790) hemitartrate is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam hemitartrate is used for the research of motor and psychiatric complications in Parkinson disease[1][2].

In Vivo

Mesdopetam (IRL790) (3.7, 11, 33, or 100 µmol/kg; s.c.) hemitartrate dose-dependently inhibits the behavioral activation following pretreatment with D-amphetamine or MK-80[1].
Mesdopetam (10 mg/kg; intraperitoneally; fourteen-week-old male C57BL/J mice) hemitartrate promotes a sedative effect similar to haloperidol with significantly reduced total distance traveled and reduced average speed[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 3.7, 11, 33, or 100 µmol/kg (synthesized in-house as HCl salt, was dissolved in physiologic saline (0.9% w/v NaCl)
Administration: s.c. was administered subcutaneously 4 min before the start of recording
Result: Dose-dependently inhibited the behavioral activation following pretreatment with D-amphetamine or MK-801.
Molecular Weight

700.77

Formula

C₁₂H₁₈FNO₃S.₁/₂C₄H₆O₆

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (29.72 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4270 mL 7.1350 mL 14.2700 mL
5 mM 0.2854 mL 1.4270 mL 2.8540 mL
10 mM 0.1427 mL 0.7135 mL 1.4270 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (2.97 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (2.97 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (2.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Mesdopetam hemitartrate
Cat. No.:
HY-109150A
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