140466-18-8
Chemical Structure
CL-184005
- CAS No.: 140466-18-8
- Formula:C33H46NO7PS
- Molecular Weight:631.76
IUPAC Name: 2-(methoxycarbonyl)-3-(tetradecyloxy)phenyl (3-((5-methylthiazol-3-ium-3-yl)methyl)phenyl) phosphate
InChIKey: VGVUQNMRGKNUJA-UHFFFAOYSA-N
SMILES: CC1=C[N+](CC2=CC=CC(OP(OC3=CC=CC(OCCCCCCCCCCCCCC)=C3C(OC)=O)([O-])=O)=C2)=CS1
Biological Activity: CL-184005 is an antagonist for platelet-activating factor (PAF), that inhibits the PAF-induced platelet aggregation with IC50 of 600 nM and 510 nM, in human and rabbit platelet-rich plasma. CL-184005 protects the rats from endotoxin-induced gastrointestinal damage and hypotension. CL-184005 exhibits potential attenuating Gram-negative bacterial sepsis[1].
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CL-184005 | CL-184005 is an antagonist for platelet-activating factor (PAF), that inhibits the PAF-induced platelet aggregation with IC50 of 600 nM and 510 nM, in human and rabbit platelet-rich plasma. CL-184005 protects the rats from endotoxin-induced gastrointestinal damage and hypotension. CL-184005 exhibits potential attenuating Gram-negative bacterial sepsis. | |||||||||||||||||||||
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Keywords
