140694-19-5
Chemical Structure
Flaccidoside II
- CAS No.: 140694-19-5
- Formula:C59H96O25
- Molecular Weight:1205.38
InChIKey: NVSLBOBPSCMMSO-XNCQHSBTSA-N
SMILES: O=C([C@](CC[C@]12C)(CCC3(C)C)[C@](C3)([H])C1=CC[C@@]4([H])[C@]2(CC[C@](C(C)5C)([H])[C@@]4(CC[C@@H]5O[C@H](OC[C@H]6O)[C@@H]([C@H]6O)O[C@H](O[C@H]7C)[C@@H]([C@@H]([C@H]7O)O)O)C)C)O[C@@H]([C@@H]([C@H]8O)O)O[C@@H]([C@H]8O)CO[C@@H]([C@@H]([C@H]9O)O)O[C@@H]([C@H]9O[C@H](O[C@H]%10C)[C@@H]([C@@H]([C@H]%10O)O)O)CO
Biological Activity: Flaccidoside II inhibits proliferation and induces apoptosis in Malignant peripheral nerve sheath tumors (MPNSTs) cell lines. Flaccidoside II ameliorates collagen-induced arthritis in mice. Flaccidoside II is an active triterpenoid saponin constituent from Anemone flaccida rhizome[1][2].
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Flaccidoside II | Flaccidoside II inhibits proliferation and induces apoptosis in Malignant peripheral nerve sheath tumors (MPNSTs) cell lines. Flaccidoside II ameliorates collagen-induced arthritis in mice. Flaccidoside II is an active triterpenoid saponin constituent from Anemone flaccida rhizome. | |||||||||||||||||||||
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- [1]. Zhang GB, et al. Corrigendum to "Flaccidoside II ameliorates collagen-induced arthritis in mice" [Eur. J. Pharmacol. 880 (2020) 173155]. Eur J Pharmacol. 2021 Apr 15;897:173963. [Content Brief]
- [2]. Han LT, et al. Triterpenoid saponin flaccidoside II from Anemone flaccida triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors via the MAPK-HO-1 pathway. Onco Targets Ther. 2016 Apr 5;9:1969-79. [Content Brief]
Keywords
