1417823-67-6
Chemical Structure
REM127
- CAS No.: 1417823-67-6
- Formula:C20H20Cl2N4S
- Molecular Weight:419.37
InChIKey: YWJORACHBFMAHI-UHFFFAOYSA-N
SMILES: ClC1=C(CCN2CCN(C3=NC(C4=CC=C(Cl)C=C4)=NS3)CC2)C=CC=C1
Biological Activity: REM127 is an orally active, blood-brain barrier-penetrant septin 6/7 molecular glue degrader. REM127 binds to SEPT6 with high affinity and promotes the assembly of SEPT2/6/7 cortical filaments, thereby normalizing cytoplasmic calcium levels, cerebrospinal fluid hyperphosphorylated tau protein levels, synaptic function and cognitive function. REM127 can be used in research related to Alzheimer's disease[1][2].
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REM127 | 99.18% | REM127 is an orally active, blood-brain barrier-penetrant septin 6/7 molecular glue degrader. REM127 binds to SEPT6 with high affinity and promotes the assembly of SEPT2/6/7 cortical filaments, thereby normalizing cytoplasmic calcium levels, cerebrospinal fluid hyperphosphorylated tau protein levels, synaptic function and cognitive function. REM127 can be used in research related to Alzheimer's disease. | ||||||||||||||||||||
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- [1]. Nuytten M, et al. Randomized phase 2a trial assessing a novel septin molecular glue in Alzheimer's disease. Alzheimers Dement. 2025;21(9):e70537. [Content Brief]
- [2]. Princen K, et al. Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease. Science. 2024;384(6699):eadd6260. [Content Brief]
Keywords
