142761-12-4
142761-12-4
Chemical Structure
(S)-(+)-O-Desmethyl Venlafaxine
- CAS No.: 142761-12-4
- Formula:C16H25NO2
- Molecular Weight:263.38
IUPAC Name: (S)-4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol
InChIKey: KYYIDSXMWOZKMP-OAHLLOKOSA-N
SMILES: OC1([C@@H](C2=CC=C(O)C=C2)CN(C)C)CCCCC1
Biological Activity: (S)-(+)-O-Desmethyl Venlafaxine is a S-enantiomer of O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine[1]. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class[2].
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(S)-(+)-O-Desmethyl Venlafaxine | (S)-(+)-O-Desmethyl Venlafaxine is a S-enantiomer of O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class. | |||||||||||||||||||||
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(S)-(+)-O-Desmethyl Venlafaxine-d6 | 99.77% | (S)-(+)-O-Desmethyl Venlafaxine-d6 is the deuterium labeled (S)-(+)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class. | ||||||||||||||||||||
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References
- [1]. Yijin Liu, et al. Development of an enantioselective assay for simultaneous separation of venlafaxine and O-desmethylvenlafaxine by micellar electrokinetic chromatography-tandem mass spectrometry: Application to the analysis of drug-drug interaction. J Chromatogr A. 2015 Nov 13;1420:119-28. [Content Brief]
- [2]. F P Bymaste, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80. [Content Brief]
