1431754-15-2
Chemical Structure
Rezuforimod
Synonym(s): AGN-232411; AG-80308; AGN-411
- CAS No.: 1431754-15-2
- Formula:C15H20BrN3O4
- Molecular Weight:386.24
InChIKey: LASJSIMHDHTROE-LBPRGKRZSA-N
SMILES: BrC(C=C1)=CC=C1NC(N[C@@H](CC(C)C)C(NCC(O)=O)=O)=O
Biological Activity: Rezuforimod (AGN-232411; AG-80308) is an ophthalmic solution targeting the formyl peptide receptor (FPR) pathway. Rezuforimod exerts anti-inflammatory effects by targeting the formyl peptide receptor pathway. Administered topically, Rezuforimod significantly reduces the corneal conjunctival staining score and improves ocular discomfort symptoms, with no serious adverse events reported and favorable overall safety profile. Rezuforimod shows remarkable potential to serve as a novel therapeutic option for dry eye disease[1][2].
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Rezuforimod | 98.63% | Rezuforimod (AGN-232411; AG-80308) is an ophthalmic solution targeting the formyl peptide receptor (FPR) pathway. Rezuforimod exerts anti-inflammatory effects by targeting the formyl peptide receptor pathway. Administered topically, Rezuforimod significantly reduces the corneal conjunctival staining score and improves ocular discomfort symptoms, with no serious adverse events reported and favorable overall safety profile. Rezuforimod shows remarkable potential to serve as a novel therapeutic option for dry eye disease. | ||||||||||||||||||||
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- [1]. Ridder III W H, et al. New drugs for the treatment of dry eye disease[J]. Clinical Optometry, 2015: 91-102.
- [2]. Cheetham J K, et al. AG-80308, a novel first-in-class ophthalmic solution for the treatment of dry eye disease[J]. Investigative Ophthalmology & Visual Science, 2024, 65(7): 2984-2984.
Keywords
