1443735-02-1
1443735-02-1
Chemical Structure
ROMK-IN-1
- CAS No.: 1443735-02-1
- Formula:C23H23FN8O2
- Molecular Weight:462.49
IUPAC Name: 3-((3R,9aS)-8-(2-(5-(1H-tetrazol-1-yl)pyridin-2-yl)acetyl)octahydropyrazino[2,1-c][1,4]oxazin-3-yl)-6-fluoro-2-methylbenzonitrile
InChIKey: XHSSYBXTQWHQSD-AVRDEDQJSA-N
SMILES: CC1=C([C@@H]2CN3[C@](CO2)(CN(C(CC4=CC=C(C=N4)N5C=NN=N5)=O)CC3)[H])C=CC(F)=C1C#N
Biological Activity: ROMK-IN-1 is an orally active inhibitor of ROMK (Kir1.1) with an IC50 of 0.073 μM. ROMK-IN-1 exhibits no activity against Kir2.1, Kir4.1, Kir7.1, Nav1.5, Cav1.2, as well as the enzymes CYP3A4, CYP2D6, and CYP2C9. ROMK-IN-1 can be used in research related to hypertension[1].
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ROMK-IN-1 | ROMK-IN-1 is an orally active inhibitor of ROMK (Kir1.1) with an IC50 of 0.073 μM. ROMK-IN-1 exhibits no activity against Kir2.1, Kir4.1, Kir7.1, Nav1.5, Cav1.2, as well as the enzymes CYP3A4, CYP2D6, and CYP2C9. ROMK-IN-1 can be used in research related to hypertension. | |||||||||||||||||||||
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