145819-92-7
Chemical Structure
Emtricitabine triphosphate
Synonym(s): (-)-Emtricitabine triphosphate
- CAS No.: 145819-92-7
- Formula:C8H13FN3O12P3S
- Molecular Weight:487.19
IUPAC Name: ((2R,5S)-5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl tetrahydrogen triphosphate
InChIKey: WIEOLFZNMKSGEX-NTSWFWBYSA-N
SMILES: O=P(O)(OP(O)(OP(O)(O)=O)=O)OC[C@@H]1O[C@H](N2C=C(F)C(N)=NC2=O)CS1
Biological Activity: Emtricitabine triphosphate ((-)-Emtricitabine triphosphate) is the phosphorylated anabolite of Emtricitabine (HY-17427). Emtricitabine is a nucleoside reverse transcriptase inhibitor. Emtricitabine is antiretroviral agent for HIV and HBV infection[1][2].
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Emtricitabine triphosphate | Emtricitabine triphosphate ((-)-Emtricitabine triphosphate) is the phosphorylated anabolite of Emtricitabine (HY-17427). Emtricitabine is a nucleoside reverse transcriptase inhibitor. Emtricitabine is antiretroviral agent for HIV and HBV infection. | |||||||||||||||||||||
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- [1]. Frasca K, et al. Emtricitabine triphosphate in dried blood spots is a predictor of viral suppression in HIV infection and reflects short-term adherence to antiretroviral therapy. J Antimicrob Chemother. 2019 May 1;74(5):1395-1401. [Content Brief]
- [2]. Bang LM, et al. Emtricitabine: an antiretroviral agent for HIV infection. Drugs. 2003;63(22):2413-24; discussion 2425-6. [Content Brief]
Keywords
