1491138-24-9
Chemical Structure
Ipatasertib tosylate
Synonym(s): GDC-0068 tosylate; RG7440 tosylate
- CAS No.: 1491138-24-9
- Formula:C31H40ClN5O5S
- Molecular Weight:630.20
InChIKey: UTUKVTLAXHISRJ-GJYOXNSLSA-N
SMILES: O=S(O)(C1=CC=C(C=C1)C)=O.ClC2=CC=C([C@@H](CNC(C)C)C(N3CCN(C4=C([C@H](C)C[C@H]5O)C5=NC=N4)CC3)=O)C=C2
Biological Activity: Ipatasertib (GDC-0068) tosylate is an orally active, highly selective and ATP-competitive pan-Akt inhibitor with IC50 values of 5, 18, 8 nM for Akt1/2/3, respectively. Ipatasertib tosylate synchronously activates FoxO3a and NF-κB through inhibition of Akt leading to p53-independent activation of PUMA. Ipatasertib tosylate also induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models[1][2].
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Ipatasertib tosylate | Ipatasertib (GDC-0068) tosylate is an orally active, highly selective and ATP-competitive pan-Akt inhibitor with IC50 values of 5, 18, 8 nM for Akt1/2/3, respectively. Ipatasertib tosylate synchronously activates FoxO3a and NF-κB through inhibition of Akt leading to p53-independent activation of PUMA. Ipatasertib tosylate also induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models. | |||||||||||||||||||||
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Keywords
