150126-87-7
Chemical Structure
CGS25155
- CAS No.: 150126-87-7
- Formula:C25H34N2O6S
- Molecular Weight:490.61
IUPAC Name: benzyl (2S,4R)-1-((2S,9R)-9-((acetylthio)methyl)-10-oxoazecane-2-carbonyl)-4-hydroxypyrrolidine-2-carboxylate
InChIKey: NGYQCCBRERZOHX-LRSLUSHPSA-N
SMILES: O=C([C@H]1NC([C@@H](CCCCCC1)CSC(C)=O)=O)N2[C@@H](C[C@H](C2)O)C(OCC3=CC=CC=C3)=O
Biological Activity: CGS25155 is an orally active neutral endopeptidase 24.11 (NEP 24.11) inhibitor with an IC50 of 3 nM. CGS25155 can slow down the degradation of the cardiac hormone atrial natriuretic peptide (ANP) and exhibits antihypertensive activity in the DOCA-salt induced rat hypertension model. CGS25155 can be used in cardiovascular disease research[1].
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CGS25155 | CGS25155 is an orally active neutral endopeptidase 24.11 (NEP 24.11) inhibitor with an IC50 of 3 nM. CGS25155 can slow down the degradation of the cardiac hormone atrial natriuretic peptide (ANP) and exhibits antihypertensive activity in the DOCA-salt induced rat hypertension model. CGS25155 can be used in cardiovascular disease research. | |||||||||||||||||||||
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Keywords
