151898-33-8
151898-33-8
Chemical Structure
SC-53606
- CAS No.: 151898-33-8
- Formula:C16H19ClN4O
- Molecular Weight:318.80
IUPAC Name: 6-chloro-N-(((1S,7aS)-hexahydro-1H-pyrrolizin-1-yl)methyl)imidazo[1,2-a]pyridine-8-carboxamide
InChIKey: SKYGATVDBNOBSE-FZMZJTMJSA-N
SMILES: O=C(NC[C@H]1[C@@]2(CCCN2CC1)[H])C3=CC(Cl)=CN4C3=NC=C4
Biological Activity: SC-53606 is a potent and selective 5-HT4 receptor antagonist, with a pA2 value of 8.13. SC-53606 acts as an antagonist of 5-HT4 receptor-mediated relaxation of Carbachol (HY-B1208)-induced contractions[1][2].
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SC-53606 | SC-53606 is a potent and selective 5-HT4 receptor antagonist, with a pA2 value of 8.13. SC-53606 acts as an antagonist of 5-HT4 receptor-mediated relaxation of Carbachol (HY-B1208)-induced contractions. | |||||||||||||||||||||
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References
- [1]. Yang DC, et al. SC-53606, a potent and selective antagonist of 5-hydroxytryptamine4 receptors in isolated rat esophageal tunica muscularis mucosae. J Pharmacol Exp Ther. 1993 Sep;266(3):1339-47. [Content Brief]
- [2]. Becker D P, et al. Design and synthesis of agonists and antagonists of the serotonin 5-HT4 receptor subtype. Pharmacochemistry Library. Elsevier, 1996, 24: 99-120.
Keywords
