1527513-89-8
1527513-89-8
Chemical Structure
TrxR inhibitor D9
- CAS No.: 1527513-89-8
- Formula:C25H20AuOPS
- Molecular Weight:596.43
InChIKey: DROLHVHTLXUINH-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)C#[C-][Au+][P](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CS4
Biological Activity: TrxR inhibitor D9 is a potent and selective inhibitor of thioredoxin reductase (TrxR), with an EC50 of 2.8 nM. TrxR inhibitor D9 has the capability to inhibit tumor proliferation both in vitro and in vivo[1][2].
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TrxR inhibitor D9 | TrxR inhibitor D9 is a potent and selective inhibitor of thioredoxin reductase (TrxR), with an EC50 of 2.8 nM. TrxR inhibitor D9 has the capability to inhibit tumor proliferation both in vitro and in vivo. | |||||||||||||||||||||
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References
- [1]. Zhang D, et, al. Synthesis and molecular recognition studies on small-molecule inhibitors for thioredoxin reductase. J Med Chem. 2014 Oct 9;57(19):8132-9. [Content Brief]
- [2]. Lin YX, et, al. pH-Sensitive Polymeric Nanoparticles with Gold(I) Compound Payloads Synergistically Induce Cancer Cell Death through Modulation of Autophagy. Mol Pharm. 2015 Aug 3;12(8):2869-78. [Content Brief]
Keywords
