155026-49-6
Chemical Structure
Z-Val-Val-Nle-diazomethylketone
Synonym(s): Z-Val-Val-Nle-CHN2
- CAS No.: 155026-49-6
- Formula:C25H37N5O5
- Molecular Weight:487.59
InChIKey: IIPZPLSBQVJCBO-BVSLBCMMSA-N
SMILES: O=C(OCC1=CC=CC=C1)N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCC)C(C=[N+]=[N-])=O)=O)=O
Biological Activity: Z-Val-Val-Nle-diazomethylketone is a cathepsin S (CATS) inhibitor. Z-Val-Val-Nle-diazomethylketone significantly inhibits the IFNg-induced upregulation of the MHCII molecules HLA-DR and Ii-p33/35 with an increase of Ii-p10 protein level. Z-Val-Val-Nle-diazomethylketone can be used for dermatological diseases like psoriasis, atopic dermatitis and actinic keratosis research[1].
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Z-Val-Val-Nle-diazomethylketone | Z-Val-Val-Nle-diazomethylketone is a cathepsin S (CATS) inhibitor. Z-Val-Val-Nle-diazomethylketone significantly inhibits the IFNg-induced upregulation of the MHCII molecules HLA-DR and Ii-p33/35 with an increase of Ii-p10 protein level. Z-Val-Val-Nle-diazomethylketone can be used for dermatological diseases like psoriasis, atopic dermatitis and actinic keratosis research. | |||||||||||||||||||||
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