155512-52-0
155512-52-0
Chemical Structure
DIPPA hydrochloride
- CAS No.: 155512-52-0
- Formula:C22H24Cl3N3OS
- Molecular Weight:484.87
IUPAC Name: (S)-2-(3,4-dichlorophenyl)-N-(1-(3-isothiocyanatophenyl)-2-(pyrrolidin-1-yl)ethyl)-N-methylacetamide hydrochloride
InChIKey: BNWYENYHNOESCX-ZMBIFBSDSA-N
SMILES: O=C(N([C@@H](C1=CC=CC(N=C=S)=C1)CN2CCCC2)C)CC3=CC=C(Cl)C(Cl)=C3.Cl
Biological Activity: DIPPA hydrochloride is an irreversible, long-lasting, selective and high affinity κ-opioid receptor antagonist. DIPPA hydrochloride can be used for the research of anxiety and antidepressant[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DIPPA hydrochloride | 99.7% | DIPPA hydrochloride is an irreversible, long-lasting, selective and high affinity κ-opioid receptor antagonist. DIPPA hydrochloride can be used for the research of anxiety and antidepressant. | ||||||||||||||||||||
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References
- [1]. Jones DC, et al. Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol. 2010;80(10):1478-1486. [Content Brief]
- [2]. Carr GV, et al. Comparison of the kappa-opioid receptor antagonist DIPPA in tests of anxiety-like behavior between Wistar Kyoto and Sprague Dawley rats. Psychopharmacology (Berl). 2010;210(2):295-302. [Content Brief]
- [3]. Costello GF, et al. 2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid kappa agonists. J Med Chem. 1991;34(1):181-189. [Content Brief]
- [4]. Chang AC, et al. kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. J Med Chem. 1994;37(26):4490-4498. [Content Brief]
Keywords
