1. DIPPA hydrochloride

DIPPA (hydrochloride) is an irreversible, long-lasting, selective and high affinity κ-opioid receptor antagonist. DIPPA (hydrochloride) can be used for the research of anxiety and antidepressant.

For research use only. We do not sell to patients.

DIPPA hydrochloride Chemical Structure

DIPPA hydrochloride Chemical Structure

CAS No. : 155512-52-0

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Description

DIPPA (hydrochloride) is an irreversible, long-lasting, selective and high affinity κ-opioid receptor antagonist. DIPPA (hydrochloride) can be used for the research of anxiety and antidepressant[1][2][3][4].

IC50 & Target

κ-opioid receptor[1]

In Vivo

DIPPA (2.5 and 5 mg/kg; s.c.) hydrochloride decreases the latency to feed in Wistar Kyoto rats, but treatment did not alter approach latencies in SD rats[2].
DIPPA (1 and 5 mg/kg; s.c.) hydrochloride high dose increases immobility in SD rats compared to the saline-treated strain control group[2].
DIPPA (5 mg/kg) hydrochloride decreases consumption in SD rats compared to the 5 mg/kg group of Wistar Kyoto rats. DIPPA hydrochloride significantly decreases burying time in both strains. DIPPA (5 mg/kg) hydrochloride decreases burying in both strains compared to the within strain control groups. DIPPA hydrochloride tends to decrease consumption in SD rats in the home cage but significantly increases feeding in the novel cage where potential anxiolytic-like effects of DIPPA hydrochloride may oppose the hypophagic effects of the compound[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar Kyoto rats and SD rats (250–300 g)[2]
Dosage: 2.5 and 5 mg/kg
Administration: S.c.
Result: Decreased the latency to feed in Wistar Kyoto rats, but treatment did not alter approach latencies in SD rats.
Animal Model: Wistar Kyoto rats and SD rats (250–300 g)[2]
Dosage: 1 and 5 mg/kg
Administration: S.c.
Result: High dose increased immobility in SD rats compared to the saline-treated strain control group.
Molecular Weight

484.87

Formula

C22H24Cl3N3OS

CAS No.
SMILES

O=C(N([C@@H](C1=CC=CC(N=C=S)=C1)CN2CCCC2)C)CC3=CC=C(Cl)C(Cl)=C3.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
DIPPA hydrochloride
Cat. No.:
HY-101223
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