156251-11-5
Chemical Structure
MART-1 (27-35) (human)
- CAS No.: 156251-11-5
- Formula:C37H67N9O11
- Molecular Weight:813.98
IUPAC Name: L-alanyl-L-alanylglycyl-L-isoleucylglycyl-L-isoleucyl-L-leucyl-L-threonyl-L-valine
InChIKey: NEHKZPHIKKEMAZ-ZFVKSOIMSA-N
SMILES: O=C(N[C@@H](C)C(NCC(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N
Biological Activity: MART-1 (27-35) (human) is the amino acid fragment spanning positions 27 to 35 of the MART-1 protein, and it represents an immunogenic epitope recognizable by HLA-A2-restricted melanoma-specific tumor-infiltrating lymphocytes (TILs). MART-1 (27-35) (human) can be used in studies related to melanoma[1][2].
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MART-1 (27-35) (human) | 98.60% | MART-1 (27-35) (human) is the amino acid fragment spanning positions 27 to 35 of the MART-1 protein, and it represents an immunogenic epitope recognizable by HLA-A2-restricted melanoma-specific tumor-infiltrating lymphocytes (TILs). MART-1 (27-35) (human) can be used in studies related to melanoma. | ||||||||||||||||||||
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- [1]. Guichard G, et al. Melanoma peptide MART-1(27-35) analogues with enhanced binding capacity to the human class I histocompatibility molecule HLA-A2 by introduction of a beta-amino acid residue: implications for recognition by tumor-infiltrating lymphocytes. J Med Chem. 2000;43(20):3803-3808. [Content Brief]
- [2]. Loftus DJ, et al. Identification of epitope mimics recognized by CTL reactive to the melanoma/melanocyte-derived peptide MART-1(27-35). J Exp Med. 1996;184(2):647-657. [Content Brief]
Keywords
