1613310-15-8
Chemical Structure
β-Hydroxymethyl chalcone
- CAS No.: 1613310-15-8
- Formula:C16H14O2
- Molecular Weight:238.28
IUPAC Name: (Z)-4-hydroxy-1,3-diphenylbut-2-en-1-one
InChIKey: YSDMFFBPTVKIEB-RVDMUPIBSA-N
SMILES: O=C(C1=CC=CC=C1)/C=C(C2=CC=CC=C2)\CO
Biological Activity: β-Hydroxymethyl chalcone is a time-dependent selective HDAC2 inhibitor, with IC50 values of 0.17 μM (24 h) and 9.19 μM (1 h). After binding to the catalytic zinc ion in the active pocket of HDAC2, β-Hydroxymethyl chalcone undergoes an intramolecular nucleophilic attack to form a cyclic product, resulting in time-dependent tight binding. β-Hydroxymethyl chalcone can be used for the study of HDAC2 selective inhibition and related epigenetic targets[1].
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β-Hydroxymethyl chalcone | β-Hydroxymethyl chalcone is a time-dependent selective HDAC2 inhibitor, with IC50 values of 0.17 μM (24 h) and 9.19 μM (1 h). After binding to the catalytic zinc ion in the active pocket of HDAC2, β-Hydroxymethyl chalcone undergoes an intramolecular nucleophilic attack to form a cyclic product, resulting in time-dependent tight binding. β-Hydroxymethyl chalcone can be used for the study of HDAC2 selective inhibition and related epigenetic targets. | |||||||||||||||||||||
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