1616953-95-7
Chemical Structure
HMRhoNox-M
Synonym(s): LysoRhoNox
- CAS No.: 1616953-95-7
- Formula:C24H24N2O3
- Molecular Weight:388.46
InChIKey: OTUKSDPZHBOXLN-UHFFFAOYSA-N
SMILES: CN(C)C1=CC=C(C2(C(C=CC([N+](C)([O-])C)=C3)=C3O4)OCC5=CC=CC=C52)C4=C1
Biological Activity: HMRhoNox-M (LysoRhoNox) is a selective fluorescent probe for labile Fe2+ with an orange fluorescence, and its excitation/emission wavelength is λₑₓ/λₑₘ = 555/575 nm. HMRhoNox-M undergoes N-oxide deoxygenation mediated by Fe2+, converting from a non-fluorescent spirocyclic closed form to a fluorescent quinone open form. HMRhoNox-M is used to detect labile Fe2+ in living cells[1][2].
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HMRhoNox-M | HMRhoNox-M (LysoRhoNox) is a selective fluorescent probe for labile Fe2+ with an orange fluorescence, and its excitation/emission wavelength is λₑₓ/λₑₘ = 555/575 nm. HMRhoNox-M undergoes N-oxide deoxygenation mediated by Fe2+, converting from a non-fluorescent spirocyclic closed form to a fluorescent quinone open form. HMRhoNox-M is used to detect labile Fe2+ in living cells. | |||||||||||||||||||||
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- [1]. Hirayama T, et al. A universal fluorogenic switch for Fe(ii) ion based on N-oxide chemistry permits the visualization of intracellular redox equilibrium shift towards labile iron in hypoxic tumor cells. Chem Sci. 2017 Jul 1;8(7):4858-4866. [Content Brief]
- [2]. Niwa M, et al. A new class of high-contrast Fe(II) selective fluorescent probes based on spirocyclized scaffolds for visualization of intracellular labile iron delivered by transferrin. Org Biomol Chem. 2014 Sep 14;12(34):6590-7. [Content Brief]
Keywords
