HMRhoNox-M
HMRhoNox-M (LysoRhoNox) is a selective fluorescent probe for labile Fe2+ with an orange fluorescence, and its excitation/emission wavelength is λₑₓ/λₑₘ = 555/575 nm. HMRhoNox-M undergoes N-oxide deoxygenation mediated by Fe2+, converting from a non-fluorescent spirocyclic closed form to a fluorescent quinone open form. HMRhoNox-M is used to detect labile Fe2+ in living cells.
For research use only. We do not sell to patients.
- CAS No.: 1616953-95-7
- Formula: C24H24N2O3
- Molecular Weight:388.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 1616953-95-7
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Molecular Weight 388.46
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Formula C24H24N2O3
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SMILES
CN(C)C1=CC=C(C2(C(C=CC([N+](C)([O-])C)=C3)=C3O4)OCC5=CC=CC=C52)C4=C1
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Synonyms
LysoRhoNox
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hirayama T, et al. A universal fluorogenic switch for Fe(ii) ion based on N-oxide chemistry permits the visualization of intracellular redox equilibrium shift towards labile iron in hypoxic tumor cells. Chem Sci. 2017 Jul 1;8(7):4858-4866. [Content Brief]
[2]. Niwa M, et al. A new class of high-contrast Fe(II) selective fluorescent probes based on spirocyclized scaffolds for visualization of intracellular labile iron delivered by transferrin. Org Biomol Chem. 2014 Sep 14;12(34):6590-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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