16286-69-4
Chemical Structure
Cetiedil citrate
- CAS No.: 16286-69-4
- Formula:C26H39NO9S
- Molecular Weight:541.65
IUPAC Name: 2-(azepan-1-yl)ethyl 2-cyclohexyl-2-(thiophen-3-yl)acetate 2-hydroxypropane-1,2,3-tricarboxylate
InChIKey: XMGJGSKRRWXOIF-UHFFFAOYSA-N
SMILES: O=C(OCCN1CCCCCC1)C(C2=CSC=C2)C3CCCCC3.OC(CC(C(O)=O)(O)CC(O)=O)=O
Biological Activity: Cetiedil citrate is a vasodilator and antihemolytic agent. Cetiedil citrate exerts anti-sickle cell anemia effects by blocking Ca2+-activated K+ channels (Gardos/KCa3.1). Cetiedil citrate is a muscarinic receptor antagonist that inhibits calcium-dependent release of acetylcholine (ACh) from mediated reconstituted proteoliposomes, with a Ki value of 5 μM. Cetiedil citrate possesses analgesic, spasmolytic and local anesthetic activities. Cetiedil citrate can be used in research related to ischemic leg pain caused by vascular diseases and sickle cell disease[1][2][3].
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Cetiedil citrate | Cetiedil citrate is a vasodilator and antihemolytic agent. Cetiedil citrate exerts anti-sickle cell anemia effects by blocking Ca2+-activated K+ channels (Gardos/KCa3.1). Cetiedil citrate is a muscarinic receptor antagonist that inhibits calcium-dependent release of acetylcholine (ACh) from mediated reconstituted proteoliposomes, with a Ki value of 5 μM. Cetiedil citrate possesses analgesic, spasmolytic and local anesthetic activities. Cetiedil citrate can be used in research related to ischemic leg pain caused by vascular diseases and sickle cell disease. | |||||||||||||||||||||
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[1]. Gaudry-Talarmain YM, et al. Cetiedil, a drug that inhibits acetylcholine release in Torpedo electric organ. J Neurochem. 1987 Aug;49(2):548-54.
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[2]. Abu-Salah KM, Gambo AH. An analysis of the mechanism by which cetiedil inhibits sickling. Life Sci. 2002 Jan 18;70(9):1003-11.
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[3]. Roxburgh CJ, et al. The synthesis and some pharmacological actions of the enantiomers of the K(+)-channel blocker cetiedil. J Pharm Pharmacol. 1996 Aug;48(8):851-7.
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Keywords
