Cetiedil citrate
Cetiedil citrate is a vasodilator and antihemolytic agent. Cetiedil citrate exerts anti-sickle cell anemia effects by blocking Ca2+-activated K+ channels (Gardos/KCa3.1). Cetiedil citrate is a muscarinic receptor antagonist that inhibits calcium-dependent release of acetylcholine (ACh) from mediated reconstituted proteoliposomes, with a Ki value of 5 μM. Cetiedil citrate possesses analgesic, spasmolytic and local anesthetic activities. Cetiedil citrate can be used in research related to ischemic leg pain caused by vascular diseases and sickle cell disease.
For research use only. We do not sell to patients.
- CAS No.: 16286-69-4
- Formula: C26H39NO9S
- Molecular Weight:541.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Calcium Channel Isoforms
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Biological Activity
Cetiedil (10-50 μM; 2 h) citrate reduces electrically evoked ACh release from Torpedo marmorata electric organ slices in a concentration-dependent manner, without altering ACh synthesis or compartmentation at 50 μM[1].
Cetiedil (10 μM; 10 min) citrate does not affect ACh synthesis or endogenous ACh compartmentation in Torpedo marmorata electric organ synaptosomes, but it significantly reduces incorporation of newly synthesized radioactive ACh into synaptic vesicles[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 16286-69-4
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Molecular Weight 541.65
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Formula C26H39NO9S
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SMILES
O=C(OCCN1CCCCCC1)C(C2=CSC=C2)C3CCCCC3.OC(CC(C(O)=O)(O)CC(O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1].
Gaudry-Talarmain YM, et al. Cetiedil, a drug that inhibits acetylcholine release in Torpedo electric organ. J Neurochem. 1987 Aug;49(2):548-54.
[Content Brief]
[2].
Abu-Salah KM, Gambo AH. An analysis of the mechanism by which cetiedil inhibits sickling. Life Sci. 2002 Jan 18;70(9):1003-11.
[Content Brief]
[3].
Roxburgh CJ, et al. The synthesis and some pharmacological actions of the enantiomers of the K(+)-channel blocker cetiedil. J Pharm Pharmacol. 1996 Aug;48(8):851-7.
[Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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