1630746-27-8
Chemical Structure
Cholesterol 24-hydroxylase-IN-3
- CAS No.: 1630746-27-8
- Formula:C13H10F3N3O2
- Molecular Weight:297.23
InChIKey: ZFIYGIJALJMZIZ-UHFFFAOYSA-N
SMILES: O=C(C1CC1)NC2=CC(C(F)(F)F)=CC(C3=CN=CO3)=N2
Biological Activity: Cholesterol 24-hydroxylase-IN-3 is an orally active, selective, and blood-brain barrier-penetrant CH24H inhibitor (IC50 = 23 nM) belonging to 1,3-oxazole derivatives. Cholesterol 24-hydroxylase-IN-3 competitively inhibits CH24H enzyme activity by using the 1,3-oxazole nitrogen atom to coordinate the heme iron and the cyclopropyl group occupying the hydrophobic pocket. Cholesterol 24-hydroxylase-IN-3 can be used for research on epilepsy and other neurological diseases[1].
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Cholesterol 24-hydroxylase-IN-3 | 98.74% | Cholesterol 24-hydroxylase-IN-3 is an orally active, selective, and blood-brain barrier-penetrant CH24H inhibitor (IC50 = 23 nM) belonging to 1,3-oxazole derivatives. Cholesterol 24-hydroxylase-IN-3 competitively inhibits CH24H enzyme activity by using the 1,3-oxazole nitrogen atom to coordinate the heme iron and the cyclopropyl group occupying the hydrophobic pocket. Cholesterol 24-hydroxylase-IN-3 can be used for research on epilepsy and other neurological diseases. | ||||||||||||||||||||
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Keywords
