1643876-33-8
Chemical Structure
BDM-2
- CAS No.: 1643876-33-8
- Formula:C25H30O4
- Molecular Weight:394.50
IUPAC Name: (S)-2-(tert-butoxy)-2-(2-(chroman-6-yl)-3-cyclopropyl-6-methylphenyl)acetic acid
InChIKey: UDFCYQOJPMKLMT-QHCPKHFHSA-N
SMILES: CC(C)(C)O[C@@H](C1=C(C2=CC=C(OCCC3)C3=C2)C(C4CC4)=CC=C1C)C(O)=O
Biological Activity: BDM-2 is an IN-LEDGF allosteric inhibitor (INLAI) of HIV-1 integrase (IN refers to integrase) (IC50=47 nM) with potent anti-Retroviral (ARV) activity. BDM-2 shows IN multimerization activation effect with an AC50 value of 20 nM. BDM-2 blocks the interaction between the catalytic core domain of IN (IN-CCD) and the Integrase binding domain of LEDGF/p75 (IBD), with an IC50 value of 0.15 μM. BDM-2 exhibits highly selective and favorable cytotoxicity[1].
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BDM-2 | 99.09% | BDM-2 is an IN-LEDGF allosteric inhibitor (INLAI) of HIV-1 integrase (IN refers to integrase) (IC50=47 nM) with potent anti-Retroviral (ARV) activity. BDM-2 shows IN multimerization activation effect with an AC50 value of 20 nM. BDM-2 blocks the interaction between the catalytic core domain of IN (IN-CCD) and the Integrase binding domain of LEDGF/p75 (IBD), with an IC50 value of 0.15 μM. BDM-2 exhibits highly selective and favorable cytotoxicity. | ||||||||||||||||||||
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Keywords
