173943-29-8
Chemical Structure
YM-44781 free acid
- CAS 番号: 173943-29-8
- Formula:C31H32Cl2FN3O2
- Molecular Weight:568.51
IUPAC Name: N-(2-(3,4-dichlorophenyl)-4-(3-oxo-3,4-dihydro-2H-spiro[isoquinoline-1,4'-piperidin]-1'-yl)butyl)-4-fluoro-N-methylbenzamide
InChIKey: MIXOPBNZLJBQJH-UHFFFAOYSA-N
SMILES: O=C(N(CC(CCN1CCC2(CC1)NC(CC3=C2C=CC=C3)=O)C4=CC=C(C(Cl)=C4)Cl)C)C5=CC=C(C=C5)F
Biological Activity: YM-44781 free acid is a non-peptide neuropeptide receptor antagonist with efficient NK(2) and NK(1) receptor antagonist activity. YM-44781 exhibits significant binding affinity on the NK(2) receptor (pKi = 9.94) and also on the NK(1) receptor Higher binding affinity (pKi = 9.09). In addition, YM-44781 also showed significant inhibitory effects on bladder contraction induced by selective NK(1) receptor agonists[1].
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YM-44781 free acid | YM-44781 free acid is a non-peptide neuropeptide receptor antagonist with efficient NK(2) and NK(1) receptor antagonist activity. YM-44781 exhibits significant binding affinity on the NK(2) receptor (pKi = 9.94) and also on the NK(1) receptor Higher binding affinity (pKi = 9.09). In addition, YM-44781 also showed significant inhibitory effects on bladder contraction induced by selective NK(1) receptor agonists. | |||||||||||||||||||||
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Keywords
