173952-44-8
173952-44-8
Chemical Structure
SYM2206
- CAS No.: 173952-44-8
- Formula:C20H22N4O3
- Molecular Weight:366.41
IUPAC Name: 8-(4-aminophenyl)-5-methyl-N-propyl-[1,3]dioxolo[4,5-g]phthalazine-6(5H)-carboxamide
InChIKey: OFUDZKKOKPGXOH-UHFFFAOYSA-N
SMILES: O=C(N1N=C(C2=CC=C(N)C=C2)C3=C(C=C4C(OCO4)=C3)C1C)NCCC
Biological Activity: SYM2206 is a potent and non-competitive AMPA receptor antagonist, with an IC50 of 1.6 μM. SYM2206 blocks Nav1.6-mediated persistent currents[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SYM2206 | 99.83% | SYM2206 is a potent and non-competitive AMPA receptor antagonist, with an IC50 of 1.6 μM. SYM2206 blocks Nav1.6-mediated persistent currents. | ||||||||||||||||||||
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References
- [1]. Bleakman D, et, al. Kainate receptor agonists, antagonists and allosteric modulators. Curr Pharm Des. 2002;8(10):873-85. [Content Brief]
- [2]. Welch NC, et al. Traditional AMPA receptor antagonists partially block Na v1.6-mediated persistent current. Neuropharmacology. 2008 Dec;55(7):1165-71. [Content Brief]
Keywords
