175617-09-1
175617-09-1
Chemical Structure
Phomopsin D
- CAS No.: 175617-09-1
- Formula:C36H47ClN6O12
- Molecular Weight:791.24
SMILES: O=C(N[C@H]1C(C)=C)[C@@H](NC)[C@@H](O)C2=CC(Cl)=C(O)C(O[C@](C)(CC)[C@@H](C(N3[C@@](C(N/C(C(NC(CC(O)=O)C(O)=O)=O)=C(C)/CC)=O)([H])C=CC3)=O)NC1=O)=C2
Biological Activity: Phomopsin D, a mycotoxin, is a derivative of Phomopsin A (HY-N6793). Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis. Phomopsin A is a noncompetitive inhibitor of the binding of radiolabeled vincristine to tubulin[1][2].
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Phomopsin D | Phomopsin D, a mycotoxin, is a derivative of Phomopsin A (HY-N6793). Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis. Phomopsin A is a noncompetitive inhibitor of the binding of radiolabeled vincristine to tubulin. | |||||||||||||||||||||
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References
- [1]. Sogahata K, et al. Biosynthetic Studies of Phomopsins Unveil Posttranslational Installation of Dehydroamino Acids by UstYa Family Proteins. Angew Chem Int Ed Engl. 2021 Dec 1;60(49):25729-25734. [Content Brief]
- [2]. Hamel E. Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B. Pharmacol Ther. 1992;55(1):31-51. [Content Brief]
Keywords
