1797406-70-2
Chemical Structure
PROTAC BRD4 Degrader-34
- CAS No.: 1797406-70-2
- Formula:C51H64ClN9O9S2
- Molecular Weight:1046.69
InChIKey: LSELSHXLKGXPPF-BOBBFQORSA-N
SMILES: CC1=C(C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCNC(C[C@@H]4N=C(C5=CC=C(Cl)C=C5)C(C(C)=C(C)S6)=C6N7C4=NN=C7C)=O)=O)=O)=O)C=C2)SC=N1
Biological Activity: PROTAC BRD4 Degrader-34 (Compound MZ2) is a selective BRD4 PROTAC degrader (pDC50 = 8.4). PROTAC BRD4 Degrader-34 can induce BD2 degradation mediated by VHL. PROTAC BRD4 Degrader-34 can be used for research on cancer. (Pink: BRD4-BD2 Ligand (HY-78695); Blue: VHL Ligand (HY-125845); Black: Linker (HY-130524))[1].
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PROTAC BRD4 Degrader-34 | PROTAC BRD4 Degrader-34 (Compound MZ2) is a selective BRD4 PROTAC degrader (pDC50 = 8.4). PROTAC BRD4 Degrader-34 can induce BD2 degradation mediated by VHL. PROTAC BRD4 Degrader-34 can be used for research on cancer. (Pink: BRD4-BD2 Ligand (HY-78695); Blue: VHL Ligand (HY-125845); Black: Linker (HY-130524)). | |||||||||||||||||||||
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Keywords