1801851-87-5
1801851-87-5
Chemical Structure
(S)-Indoximod-d3
Synonym(s): 1-Methyl-L-tryptophan-d3;(S)-NLG-8189-d3
- CAS No.: 1801851-87-5
- Formula:C12H11D3N2O2
- Molecular Weight:221.27
IUPAC Name: 1-(methyl-d3)-L-tryptophan
InChIKey: ZADWXFSZEAPBJS-ASGODXDTSA-N
SMILES: N[C@@H](CC1=CN(C([2H])([2H])[2H])C2=CC=CC=C12)C(O)=O
Biological Activity: (S)-Indoximod-d3 is the deuterium labeled (S)-Indoximod. (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(S)-Indoximod-d3 | 99.0% | (S)-Indoximod-d3 is the deuterium labeled (S)-Indoximod. (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer. | ||||||||||||||||||||
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(S)-Indoximod | 99.47% | (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO) (Ki: 19 μM). (S)-Indoximod can be used for the research of cancer and neurological disease. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Huang GL, et, al. PEG-Poly(1-Methyl-l-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase. Nanomaterials (Basel). 2019 May 9;9(5):719. [Content Brief]
- [3]. Liu X, et, al. 1-L-MT, an IDO inhibitor, prevented colitis-associated cancer by inducing CDC20 inhibition-mediated mitotic death of colon cancer cells. Int J Cancer. 2018 Sep 15;143(6):1516-1529. [Content Brief]
Keywords
