1816990-29-0
Chemical Structure
K-Opioid receptor agonist-1
- CAS No.: 1816990-29-0
- Formula:C22H29Cl2N3O3
- Molecular Weight:454.39
InChIKey: PAVYSOUZQLFNIW-IRFCIJBXSA-N
SMILES: ClC(C=C1CC(N2[C@@]3([H])[C@@](CCC[C@@H]3N4CCCC4)([H])N(CC2)C(OC)=O)=O)=C(C=C1)Cl
Biological Activity: K-Opioid receptor agonist-1 (Compound 5a) is an agonist for κ-Opioid receptor with Ki of 0.25 nM and EC50 of 2 nM. K-Opioid receptor agonist-1 is blood brain barrier (BBB) penetrate (brain/plasma ratios of 0.50 to 0.65). K-Opioid receptor agonist-1 exhibits anti-inflammatory activity in dermatitis models induced by Arachidonic acid (HY-109590) or oxazolidinone[1].
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K-Opioid receptor agonist-1 | K-Opioid receptor agonist-1 (Compound 5a) is an agonist for κ-Opioid receptor with Ki of 0.25 nM and EC50 of 2 nM. K-Opioid receptor agonist-1 is blood brain barrier (BBB) penetrate (brain/plasma ratios of 0.50 to 0.65). K-Opioid receptor agonist-1 exhibits anti-inflammatory activity in dermatitis models induced by Arachidonic acid (HY-109590) or oxazolidinone. | |||||||||||||||||||||
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Keywords
