183322-18-1
Chemical Structure
4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline
- CAS No.: 183322-18-1
- Formula:C14H17ClN2O4
- Molecular Weight:312.75
IUPAC Name: 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
InChIKey: ZPJLDMNVDPGZIU-UHFFFAOYSA-N
SMILES: ClC1=NC=NC2=C1C=C(OCCOC)C(OCCOC)=C2
Biological Activity: 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline (Compound 11 and 15) is a building block and synthetic intermediate, which can be used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone deacetylase (HDAC) inhibitors, and anticancer agents. 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline can also be used to synthesize EGFR inhibitors, including Erlotinib (HY-50896), with antiproliferative activity[1][2].
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4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline | 99.55% | 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline (Compound 11 and 15) is a building block and synthetic intermediate, which can be used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone deacetylase (HDAC) inhibitors, and anticancer agents. 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline can also be used to synthesize EGFR inhibitors, including Erlotinib (HY-50896), with antiproliferative activity. | ||||||||||||||||||||
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- [1]. Zhang G, et al. Isolation of highly pure erlotinib hydrochloride by recrystallization after nucleophilic substitution of an impurity with piperazine[J]. Research on Chemical Intermediates, 2013, 39(6): 2303-2309.
- [2]. Knesl P, et al. Improved synthesis of substituted 6,7-dihydroxy-4-quinazolineamines: tandutinib, erlotinib and gefitinib. Molecules. 2006 Apr 10;11(4):286-97. [Content Brief]
