Improved synthesis of substituted 6,7-dihydroxy-4-quinazolineamines: tandutinib, erlotinib and gefitinib

  • Molecules. 2006 Apr 10;11(4):286-97. doi: 10.3390/11040286.
Petr Knesl  1 ,  Dirk Röseling ,  Ulrich Jordis
Affiliations
  • 1. Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, 1060 Vienna, Austria.
PMID: 17962760 DOI: 10.3390/11040286
Abstract

The synthesis of three substituted 6,7-dihydroxy-4-quinazolineamines: tandutinib (1), erlotinib (2) and gefitinib (3) in improved yields is reported. The intermediates were characterized by NMR and the purities determined by HPLC.

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