18449-25-7
Chemical Structure
Dehydroeburiconic acid
- CAS No.: 18449-25-7
- Formula:C31H46O3
- Molecular Weight:466.70
IUPAC Name: (R)-6-methyl-5-methylene-2-((5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-3-oxo-2,3,4,5,6,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)heptanoic acid
InChIKey: DVXFDXIVWQWLIU-DIQRFASRSA-N
SMILES: C[C@]12C3=CC[C@](C(C)(C(CC4)=O)C)([H])[C@@]4(C)C3=CC[C@@]1([C@@](CC2)([H])[C@H](C(O)=O)CCC(C(C)C)=C)C
Biological Activity: Dehydroeburiconic acid is a DNA polymerase α/β inhibitor, with IC50 values of 40.8 μM and 30.0 μM against calf DNA polymerase α and rat DNA polymerase β, respectively. Dehydroeburiconic acid can be used in studies related to lanostane-type triterpenoids and DNA polymerase[1][2][3].
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Dehydroeburiconic acid | Dehydroeburiconic acid is a DNA polymerase α/β inhibitor, with IC50 values of 40.8 μM and 30.0 μM against calf DNA polymerase α and rat DNA polymerase β, respectively. Dehydroeburiconic acid can be used in studies related to lanostane-type triterpenoids and DNA polymerase. | |||||||||||||||||||||
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References
- [1]. Kaminaga T, et al. Inhibitory Effect of Poria cocos on 12-O-Tetradecanoylphorbol-13-Acetate-Induced Ear Oedema and Tumour Promotion in Mouse Skin. Phytotherapy Research. 1996;10:581-584.
- [2]. Akihisa T, et al. Dehydrotrametenonic acid and dehydroeburiconic acid from Poria cocos and their inhibitory effects on eukaryotic DNA polymerase alpha and beta. Bioscience, biotechnology, and biochemistry. 2004 Feb;68(2):448-50.
- [3]. Feng W, et al. A new drimane sesquiterpenoid and a new triterpene lactone from fungus of Fomes officinalis. Journal of Asian Natural Products Research. 2015.
