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Art. -Nr.: HY-N21925

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Dehydroeburiconic acid

Dehydroeburiconic acid is a DNA polymerase α/β inhibitor, with IC₅₀ values of 40.8 μM and 30.0 μM against calf DNA polymerase α and rat DNA polymerase β, respectively. Dehydroeburiconic acid can be used in studies related to lanostane-type triterpenoids and DNA polymerase.

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CAS. Nr.: 18449-25-7
Formel: C₃₁H₄₆O₃
Molecular Weight:466.70

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dehydroeburiconic acid Chemical Structure

CAS. Nr.: 18449-25-7

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Preis

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[2]

Calf pol α

40.8 μM (IC₅₀)

Rat pol β

30 μM (IC₅₀)

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In Vitro

Dehydroeburiconic acid (compound 5) exhibits no cytotoxic activity against human leukemia HL-60 cells, human hepatocellular carcinoma Bel-7402 cells, and human nasopharyngeal carcinoma KB cells, with IC₅₀ values >200 μM for all cell lines^[1].
Dehydroeburiconic acid (compound 2) exhibits inhibitory effects on calf thymus DNA polymerase α with an IC₅₀ value of 40.6 μM; it also inhibits recombinant rat DNA polymerase β, with an IC₅₀ value of 30.0 μM^[2].
Dehydroeburiconic acid (compound 7a) (3 h) is a lanostane-type triterpenic acid that is isolated from the methanol extract of the sclerotia of Poria cocos and structurally identified^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

human leukemia HL-60 cells, human hepatoma Bel-7402 cells, human nasopharyngeal carcinoma KB cells
Concentration:

up to 200 μM
Incubation Time:

24 h (Bel-7402, KB); MTT assay incubation duration (HL-60)
Result:

Showed no cytotoxic activity against HL-60, Bel-7402, or KB cells at tested concentrations.
Exhibited IC₅₀ values greater than 200 μM for all three cell lines.

In Vivo

Dehydroeburiconic acid (compound 7a) (27 μg/ear; topical) exhibits anti-inflammatory activity against TPA (HY-18739)-induced mouse ear oedema with an ID₅₀ of 27 μg/ear, similar to Hydrocortisone (HY-N0583)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR mice (female)^[3]
Dosage:

27 μg/ear
Administration:

topical
Result:

Determined an ID₅₀ of 27 μg/ear against TPA-induced ear oedema.

Chemical Information

CAS. Nr. 18449-25-7
Molecular Weight 466.70
Formel C₃₁H₄₆O₃
SMILES

C[C@]12C3=CC[C@](C(C)(C(CC4)=O)C)([H])[C@@]4(C)C3=CC[C@@]1([C@@](CC2)([H])[C@H](C(O)=O)CCC(C(C)C)=C)C
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
Fomes officinalis
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Kaminaga T, et al. Inhibitory Effect of Poria cocos on 12-O-Tetradecanoylphorbol-13-Acetate-Induced Ear Oedema and Tumour Promotion in Mouse Skin. Phytotherapy Research. 1996;10:581-584.

[2]. Akihisa T, et al. Dehydrotrametenonic acid and dehydroeburiconic acid from Poria cocos and their inhibitory effects on eukaryotic DNA polymerase alpha and beta. Bioscience, biotechnology, and biochemistry. 2004 Feb;68(2):448-50.

[3]. Feng W, et al. A new drimane sesquiterpenoid and a new triterpene lactone from fungus of Fomes officinalis. Journal of Asian Natural Products Research. 2015.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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Dehydroeburiconic acid

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