Dehydroeburiconic acid
Dehydroeburiconic acid is a DNA polymerase α/β inhibitor, with IC50 values of 40.8 μM and 30.0 μM against calf DNA polymerase α and rat DNA polymerase β, respectively. Dehydroeburiconic acid can be used in studies related to lanostane-type triterpenoids and DNA polymerase.
For research use only. We do not sell to patients.
- CAS No.: 18449-25-7
- Formula: C31H46O3
- Molecular Weight:466.70
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
Description
IC50 & Target
[2]|
Calf pol α 40.8 μM (IC50) |
Rat pol β 30 μM (IC50) |
In Vitro
Dehydroeburiconic acid (compound 5) exhibits no cytotoxic activity against human leukemia HL-60 cells, human hepatocellular carcinoma Bel-7402 cells, and human nasopharyngeal carcinoma KB cells, with IC50 values >200 μM for all cell lines[1].
Dehydroeburiconic acid (compound 2) exhibits inhibitory effects on calf thymus DNA polymerase α with an IC50 value of 40.6 μM; it also inhibits recombinant rat DNA polymerase β, with an IC50 value of 30.0 μM[2].
Dehydroeburiconic acid (compound 7a) (3 h) is a lanostane-type triterpenic acid that is isolated from the methanol extract of the sclerotia of Poria cocos and structurally identified[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human leukemia HL-60 cells, human hepatoma Bel-7402 cells, human nasopharyngeal carcinoma KB cells
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Concentration:up to 200 μM
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Incubation Time:24 h (Bel-7402, KB); MTT assay incubation duration (HL-60)
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Result:Showed no cytotoxic activity against HL-60, Bel-7402, or KB cells at tested concentrations.
Exhibited IC50 values greater than 200 μM for all three cell lines.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice (female)[3]
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Dosage:27 μg/ear
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Administration:topical
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Result:Determined an ID50 of 27 μg/ear against TPA-induced ear oedema.
Chemical Information
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CAS No. 18449-25-7
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Molecular Weight 466.70
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Formula C31H46O3
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SMILES
C[C@]12C3=CC[C@](C(C)(C(CC4)=O)C)([H])[C@@]4(C)C3=CC[C@@]1([C@@](CC2)([H])[C@H](C(O)=O)CCC(C(C)C)=C)C
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Structure Classification
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Initial Source
Fomes officinalis
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dehydroeburiconic acid Related Classifications
HY-N21925 Related Classifications
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Keywords
- Dehydroeburiconic acid
- 18449-25-7
- DNA/RNA Synthesis
- human nasopharyngeal carcinoma KB
- lanostane-type triterpene acid
- TPA-induced skin tumour promotion
- cancer cell growth
- human hepatoma Bel-7402
- Poria cocos sclerotium
- TPA-induced inflammatory ear oedema
- human leukemia HL-60
- rat DNA polymerase β
- calf DNA polymerase α
- Inhibitor
- inhibitor
- inhibit