184901-82-4
Chemical Structure
AAF-CMK TFA
Synonym(s): Ala-ala-phe-chloromethylketone tfa; N-Ala-Ala-Phe-CMK; Tripeptidyl Peptidase inhibitor II
- CAS No.: 184901-82-4
- Formula:C18H23ClF3N3O5
- Molecular Weight:453.84
IUPAC Name: (S)-2-amino-N-((S)-1-amino-1-oxopropan-2-yl)-N-((S)-4-chloro-3-oxo-1-phenylbutan-2-yl)propanamide 2,2,2-trifluoroacetate
InChIKey: MFLWHUDUNKUYEQ-SQRKDXEHSA-N
SMILES: C[C@@H](C(N)=O)N(C([C@H](C)N)=O)[C@@H](CC1=CC=CC=C1)C(CCl)=O.O=C(O)C(F)(F)F
Biological Activity: AAF-CMK TFA (Ala-ala-phe-chloromethylketone tfa; N-Ala-Ala-Phe-CMK) is a subtilisin-type serine peptidase that removes tripeptides from the free NH2 termini of oligopeptides. AAF-CMK TFA is an irreversible inhibitor of TPPII and is typically used at concentrations of 10-100 μM. It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at a concentration of 50 μM.
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AAF-CMK TFA | AAF-CMK TFA (Ala-ala-phe-chloromethylketone tfa; N-Ala-Ala-Phe-CMK) is a subtilisin-type serine peptidase that removes tripeptides from the free NH2 termini of oligopeptides. AAF-CMK TFA is an irreversible inhibitor of TPPII and is typically used at concentrations of 10-100 μM. It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at a concentration of 50 μM. | |||||||||||||||||||||
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Keywords
