186040-50-6
Chemical Structure
Paclitaxel ceribate
Synonym(s): Protaxel
- CAS No.: 186040-50-6
- Formula:C51H57NO18
- Molecular Weight:971.99
IUPAC Name: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-9-(((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-4-(((2,3-dihydroxypropoxy)carbonyl)oxy)-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-3,4,4a,5,6,9,10,11,12,12a-decahydro-1H-7,11-methanocyclodeca[3,4]
InChIKey: HSUDWURBWSUCOB-JPHWUADUSA-N
SMILES: CC(O[C@]12[C@]([C@@H]3OC(C4=CC=CC=C4)=O)([H])[C@@]([C@@H](OC(OCC(O)CO)=O)C[C@@]1([H])OC2)(C([C@@H](C5=C(C)[C@@H](OC([C@H](O)[C@H](C6=CC=CC=C6)NC(C7=CC=CC=C7)=O)=O)C[C@]3(O)C5(C)C)OC(C)=O)=O)C)=O
Biological Activity: Paclitaxel ceribate is the ester form of paclitaxel, a natural antineoplastic agent that stabilizes tubulin polymerization. Paclitaxel causes mitotic arrest and induces apoptosis, ultimately leading to cell death. Paclitaxel also induces autophagy[1][2].
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Paclitaxel ceribate | Paclitaxel ceribate is the ester form of paclitaxel, a natural antineoplastic agent that stabilizes tubulin polymerization. Paclitaxel causes mitotic arrest and induces apoptosis, ultimately leading to cell death. Paclitaxel also induces autophagy. | |||||||||||||||||||||
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- [1]. Choi YH, et al. Taxol-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells. Oncol Rep. 2012 Dec;28(6):2163-9. [Content Brief]
- [2]. Dziadyk JM, et al. Paclitaxel-induced apoptosis may occur without a prior G2/M-phase arrest. Anticancer Res. 2004 Jan-Feb;24(1):27-36. [Content Brief]
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