1889218-34-1
Chemical Structure
LY3526318
- CAS No.: 1889218-34-1
- Formula:C23H19F3N10O4
- Molecular Weight:556.46
InChIKey: UMRMICUACMEDEJ-NSHDSACASA-N
SMILES: FC(F)(F)C1=NC=C(C=N1)C2=NC(NC([C@@H](N3C4=C(N=C3)N(C(N(C4=O)CC5=NC(C)=NO5)=O)C)C)=O)=CC=C2
Biological Activity: LY3526318 is an orally active, selective TRPA1 antagonist (IC50=5-6μM). LY3526318 blocks TRPA1 channels, inhibits pain signal transduction mediated by the channel, and exerts analgesic activity. LY3526318 is mainly used in the research of chronic pain-related fields, such as diabetic peripheral neuropathy, chronic low back pain, and pain caused by osteoarthritis[1][2].
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LY3526318 | 99.92% | LY3526318 is an orally active, selective TRPA1 antagonist (IC50=5-6μM). LY3526318 blocks TRPA1 channels, inhibits pain signal transduction mediated by the channel, and exerts analgesic activity. LY3526318 is mainly used in the research of chronic pain-related fields, such as diabetic peripheral neuropathy, chronic low back pain, and pain caused by osteoarthritis. | ||||||||||||||||||||
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- [1]. Bamps D, et al. TRPA1 Antagonist LY3526318 Inhibits the Cinnamaldehyde-Evoked Dermal Blood Flow Increase: Translational Proof of Pharmacology. Clin Pharmacol Ther. 2023 Nov;114(5):1093-1103. [Content Brief]
- [2]. Broad LM, et al. Preclinical and clinical evaluation of a novel TRPA1 antagonist LY3526318. Pain. 2025 Apr 18. [Content Brief]
Keywords
