1936472-36-4
1936472-36-4
Chemical Structure
JNJ-38877605-d1
- CAS No.: 1936472-36-4
- Formula:C19H12DF2N7
- Molecular Weight:378.36
InChIKey: JRWCBEOAFGHNNU-BNEYPBHNSA-N
SMILES: FC(C1=CC=C(N=C([2H])C=C2)C2=C1)(F)C3=NN=C4N3N=C(C5=CN(C)N=C5)C=C4
Biological Activity: JNJ-38877605-d1 (compound DO-2) is a highly selective MNNG HOS transforming (MET) inhibitor. JNJ-38877605-d1 is thought to diminish the formation of the Aldehyde Oxidase 1 inactive metabolite M3[1].
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JNJ-38877605-d1 | JNJ-38877605-d1 (compound DO-2) is a highly selective MNNG HOS transforming (MET) inhibitor. JNJ-38877605-d1 is thought to diminish the formation of the Aldehyde Oxidase 1 inactive metabolite M3. | |||||||||||||||||||||
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JNJ-38877605 | 99.95% | JNJ-38877605 is an orally active ATP-competitive inhibitor of c-Met with an IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases. JNJ-38877605 inhibits c-Met phosphorylation and regulates lipid accumulation. JNJ-38877605 can be used for tumor and metabolic disease reseach. | ||||||||||||||||||||
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References
Keywords
