193809-84-6
Chemical Structure
MMI-166
- CAS. Nr.: 193809-84-6
- Formula:C24H20N6O4S
- Molecular Weight:488.52
InChIKey: NLABJQQLMHAJIL-JOCHJYFZSA-N
SMILES: O=S(N[C@@H](C(O)=O)CC1=CNC2=CC=CC=C12)(C3=CC=C(C4=NN(C5=CC=CC=C5)N=N4)C=C3)=O
Biological Activity: MMI-166 is an orally active selective matrix metalloproteinase (MMP) inhibitor (MMP-2 (IC50 = 2 nM), MMP-9 (IC50 = 53 nM)). MMI-166 can prevent tumor invasion, metastasis and angiogenic, and promotes apoptosis. MMI-166 dose not only directly inhibits the enzymatic activity of MMP-2 and MMP-9 but also downregulates their protein synthesis and expression levels at the post-transcriptional level. MMI-166 can be used in research on colon cancer, head and neck squamous cell carcinoma, microglioma, lung cancer, and pancreatic cancer[1][2][3][4][5].
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MMI-166 | MMI-166 is an orally active selective matrix metalloproteinase (MMP) inhibitor (MMP-2 (IC50 = 2 nM), MMP-9 (IC50 = 53 nM)). MMI-166 can prevent tumor invasion, metastasis and angiogenic, and promotes apoptosis. MMI-166 dose not only directly inhibits the enzymatic activity of MMP-2 and MMP-9 but also downregulates their protein synthesis and expression levels at the post-transcriptional level. MMI-166 can be used in research on colon cancer, head and neck squamous cell carcinoma, microglioma, lung cancer, and pancreatic cancer. | |||||||||||||||||||||
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- [1]. Oba K, et al. Prevention of liver metastasis of human colon cancer by selective matrix metalloproteinase inhibitor MMI-166. Cancer Lett. 2002 Jan 10;175(1):45-51. [Content Brief]
- [2]. Katori H,et al. Reduction of in vivo tumor growth by MMI-166, a selective matrix metalloproteinase inhibitor, through inhibition of tumor angiogenesis in squamous cell carcinoma cell lines of head and neck. Cancer Lett. 2002 Apr 25;178(2):151-9. [Content Brief]
- [3]. Nakabayashi H, et al. Anti-invasive and antiangiogenic effects of MMI-166 on malignant glioma cells. BMC Cancer. 2010 Jun 29;10:339. [Content Brief]
- [4]. Fujino H, et al. Matrix metalloproteinase inhibitor MMI-166 inhibits lymphogenous metastasis in an orthotopically implanted model of lung cancer. Mol Cancer Ther. 2005 Sep;4(9):1409-16. [Content Brief]
- [5]. Gao CC, et al. MMI-166, a selective matrix metalloproteinase inhibitor, promotes apoptosis in human pancreatic cancer. Med Oncol. 2015 Jan;32(1):418. [Content Brief]
Keywords
