198696-03-6
Chemical Structure
DC271
- No. CAS: 198696-03-6
- Formula:C23H25NO2
- Molecular Weight:347.45
IUPAC Name: 4-((1-isopropyl-4,4-dimethyl-1,2,3,4-tetrahydroquinolin-6-yl)ethynyl)benzoic acid
InChIKey: OCMSZODRCJAGHL-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(C#CC2=CC3=C(N(C(C)C)CCC3(C)C)C=C2)C=C1
Biological Activity: DC271 is a RAR agonist and synthetic retinoid that binds to the retinoid-binding site of cellular retinoic acid-binding protein II (CRBP-II). DC271 exhibits solvatochromic fluorescence properties: it produces intense blue-shifted emission in nonpolar environments and weak red-shifted emission in polar environments, and its severe fluorescence quenching in aqueous solutions can be reversed by embedding in the hydrophobic retinoid-binding protein pocket. DC271 enables direct detection of the binding between unlabeled compounds and related retinoid-binding proteins via fluorescence competition assays (Ex/Em = 355 nm/460 nm)[1].
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DC271 | 97.7% | DC271 is a RAR agonist and synthetic retinoid that binds to the retinoid-binding site of cellular retinoic acid-binding protein II (CRBP-II). DC271 exhibits solvatochromic fluorescence properties: it produces intense blue-shifted emission in nonpolar environments and weak red-shifted emission in polar environments, and its severe fluorescence quenching in aqueous solutions can be reversed by embedding in the hydrophobic retinoid-binding protein pocket. DC271 enables direct detection of the binding between unlabeled compounds and related retinoid-binding proteins via fluorescence competition assays (Ex/Em = 355 nm/460 nm). | ||||||||||||||||||||
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Keywords
