2009273-67-8
2009273-67-8
Chemical Structure
GNE-6640
- CAS No.: 2009273-67-8
- Formula:C20H18N4O
- Molecular Weight:330.38
IUPAC Name: 4-(2-amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl)phenol
InChIKey: ZHYXJQQBKROZDX-UHFFFAOYSA-N
SMILES: OC1=CC=C(C2=C(CC)C(C3=CC4=C(NN=C4)C=C3)=CN=C2N)C=C1
Biological Activity: GNE-6640 is a selective and non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7, USP7 catalytic domain, full length USP47 and Ub-MDM2, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GNE-6640 | 99.91% | GNE-6640 is a selective and non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7, USP7 catalytic domain, full length USP47 and Ub-MDM2, respectively. | ||||||||||||||||||||
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References
- [1]. Kategaya L, et al. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017 Oct 26;550(7677):534-538. [Content Brief]
- [2]. Tanguturi P, et al. The role of deubiquitinating enzymes in cancer drug resistance. Cancer Chemother Pharmacol. 2020 Apr;85(4):627-639. [Content Brief]
Keywords
