2035011-97-1
Chemical Structure
SPT-IN-2
- CAS No.: 2035011-97-1
- Formula:C26H22ClF3N6O2
- Molecular Weight:542.94
InChIKey: RULGWHWQJLRHOQ-IEBWSBKVSA-N
SMILES: O=C(C1=CC(C(F)(F)F)=NN1C)N[C@H]2[C@@H](C3=CC=CC=C3)CN(CC2)C(C4=CC5=C(N=CC=N5)C(Cl)=C4)=O
Biological Activity: SPT-IN-2 is an orally active serine palmitoyltransferase (SPT) inhibitor (with an IC50 of 0.71 nM against human SPT2). SPT-IN-2 inhibits ceramide synthesis, suppresses cancer cell growth, and exhibits in vivo anti-tumor activity, favorable metabolic stability and cell membrane permeability in xenograft mouse models. SPT-IN-2 blocks the de novo sphingolipid synthesis pathway, significantly reducing intracellular ceramide levels and the levels of 3-ketodihydrosphingosine (3-KDS), the immediate downstream product of SPT. SPT-IN-2 can be used in research related to lung adenocarcinoma, acute promyelocytic leukemia and breast cancer[1].
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SPT-IN-2 | 99.45% | SPT-IN-2 is an orally active serine palmitoyltransferase (SPT) inhibitor (with an IC50 of 0.71 nM against human SPT2). SPT-IN-2 inhibits ceramide synthesis, suppresses cancer cell growth, and exhibits in vivo anti-tumor activity, favorable metabolic stability and cell membrane permeability in xenograft mouse models. SPT-IN-2 blocks the de novo sphingolipid synthesis pathway, significantly reducing intracellular ceramide levels and the levels of 3-ketodihydrosphingosine (3-KDS), the immediate downstream product of SPT. SPT-IN-2 can be used in research related to lung adenocarcinoma, acute promyelocytic leukemia and breast cancer. | ||||||||||||||||||||
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Keywords
