2044497-76-7
2044497-76-7
Chemical Structure
CGK012
- CAS No.: 2044497-76-7
- Formula:C20H23NO5
- Molecular Weight:357.40
InChIKey: JWNFWIWPOYKOSQ-KRWDZBQOSA-N
SMILES: O=C(O[C@H]1CC2=CC(C=CC3=O)=C(O3)C=C2OC1(C)C)NC4CCCC4
Biological Activity: CKG012 is an inhibitor for Wnt/βcatenin signaling pathway. CGK012 inhibits release of HMGB1 and transcription of β-catenin, exhibits attenuating activities against cecal ligation and puncture (CLP)-induced sepsis and multiple myeloma cancer[1][2].
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CGK012 | 99.96% | CKG012 is an inhibitor for Wnt/βcatenin signaling pathway. CGK012 inhibits release of HMGB1 and transcription of β-catenin, exhibits attenuating activities against cecal ligation and puncture (CLP)-induced sepsis and multiple myeloma cancer. | ||||||||||||||||||||
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References
- [1]. Park YJ, et al., Antiseptic Functions of CGK012 against HMGB1-Mediated Septic Responses. Int J Mol Sci. 2024 Mar 4;25(5):2976. [Content Brief]
- [2]. Choi PJ,et al., Anti-proliferative activity of CGK012 against multiple myeloma cells via Wnt/β-catenin signaling attenuation. Leuk Res. 2017 Sep;60:103-108. [Content Brief]
Keywords
